Gregory House, M.D., is a fictional character and protagonist of the American medical drama House. Portrayed by Hugh Laurie, the character is a maverick medical genius, a diagnostician with specializations in infectious diseases and nephrology. He works as the Chief of Diagnostic Medicine at the fictional Princeton-Plainsboro Teaching Hospital, and there heads a team of diagnosticians. House's character has been described as a "misanthrope", a "cynic", a narcissist and a "curmudgeon".
In the series, the character's unorthodox diagnostic approaches, radical therapeutic motives, and stalwart rationality has resulted in much conflict between him and his colleagues. House is also often portrayed as lacking sympathy for his patients, a practice that allots him the time to solve pathological enigmas. The character is partly inspired by Sherlock Holmes and Perry Cox. The reference made full circle when, in the Scrubs episode "My House", the character J.D. compared Cox to Dr. House.
A portion of the show's plot centers on House's habitual use of Vicodin to manage pain stemming from an infarction in his quadriceps muscle some years earlier, an injury that forces him to walk with a cane. This addiction is also one of the many parallels to Sherlock Holmes, who was addicted to cocaine.
Throughout the series run, the character has received positive reviews.Tom Shales of The Washington Post called House "the most electrifying character to hit television in years." In 2008, Gregory House was voted second sexiest TV doctor ever, behind Dr. Doug Ross (George Clooney) from ER.For his portrayal of Gregory House, Hugh Laurie has won various awards, including two Golden Globe Awards for Best Actor in a Television Drama Series and a Screen Actors Guild Award for Best Actor from Drama Series. Laurie also earned Primetime Emmy Award nominations in 2005, 2007, 2008 and 2009.